Zitat des Tages über Genom / Genome:
There have been lots of stories written about all the hype over getting the genome done and the letdown of not discovering lots of cures right after.
Living in your genome is the history of our species.
Understanding how Cas9 is able to locate specific 20-base-pair target sequences within genomes that are millions to billions of base pairs long may enable improvements to gene targeting and genome editing efforts in bacteria and other types of cells.
Genomics is a new idea. Like the PC, it's not obvious at first that anyone would want one. It's like, 'Hey, we've already got one genome, why do we need more?'
While the Environmental Genome Project does not seek to assign allele frequencies, we are aware of the importance of accurate allele frequency estimates for future epidemiologic studies and the large sample sizes such estimates will require.
Why do people believe that there are dangerous implications of the idea that the mind is a product of the brain, that the brain is organized in part by the genome, and that the genome was shaped by natural selection?
The overall view of the human genome project has been one of great excitement and positive press, but there are people who have concerns that are quite reasonable, and they are frightened of things they don't understand.
By being able to write a genome and plug it into an organism, the software, if you will, changes the hardware.
Most people are excited about themselves. Personal genome will deliver for inexpensively something about science to which you can relate. Just like computers are becoming something to which you can relate. It should be even easier to relate to your own biology, and I hope that will be one of the ways we get broader literacy in science.
Each part of our genome is unique. We would not be alive if there was not a single mathematical solution for our chromosomes. We would just be scrambled goo.
It is important to consider whether the sample size selected by the Environmental Genome Project will provide sufficient power to discover most alleles relevant to gene-environment interactions.
One of the good things about the public Human Genome Project is that the U.S. Department of Energy and the National Institutes of Health spent a part of their budget on the ethical, legal, and social implications of their research.
The virus that causes AIDS is the trickiest pathogen scientists have ever confronted. It mutates furiously, it has decoys to evade the immune system, it attacks the very cells that are trying to fight it, and it quickly hides itself in your genome.
If I had a weak ego, and doubts about this, the first genome would not yet have been completed with US and UK government funding.
I firmly believe that the next great breakthrough in bioscience could come from a 15-year-old who downloads the human genome in Egypt.
We live in a dancing matrix of viruses; they dart, rather like bees, from organism to organism, from plant to insect to mammal to me and back again, and into the sea, tugging along pieces of this genome, strings of genes from that, transplanting grafts of DNA, passing around heredity as though at a great party.
Simple genome engineering of bacteria and yeast is just the beginning of the rise of the true biohackers. This is a community of several thousand people, with skill sets ranging from self-taught software hackers to biology postdocs who are impatient with the structure of traditional institutional lab work.
Sometimes it is claimed by those who argue that race is just a social construct that the human genome project shows that because people share roughly 99% of their genes in common, that there are no races. This is silly.
Your genome isn't really secret.
What I really wanted was for everybody to have their genome and, ideally, everybody to share their genome, and for that, we needed to bring the price way down.
I never dreamed that in my lifetime my own genome would be sequenced.
One of the responsibilities faced by the Environmental Genome Project is to provide the science base upon which society can make better informed risk management decisions.
During this period, I became interested in how the new techniques of cloning and sequencing DNA could influence the study of genetics and I was an early and active proponent of the Human Genome Sequencing Project.
I am thrilled to see my genome.
For each gene in your genome, you quite often get a different version of that gene from your father and a different version from your mother. We need to study these relationships across a very large number of people.
An important finding is that by determining the genome sequences of an entire family, one can identify many DNA sequencing errors and thus greatly increase the accuracy of the data. This will ultimately help us understand the role of genetic variations in the diagnosis, treatment, and prevention of disease.
If we can put a man on the moon and sequence the human genome, we should be able to devise something close to a universal digital public library.
I respect and value the ideals of rugged individualism and self-reliance. But rugged individualism didn't defeat the British, it didn't get us to the moon, build our nation's highways, or map the human genome. We did that together. This is the high call of patriotism.
Medicine will be personalized and preventive: Your genome might predict that you have an 80 percent chance of breast cancer by the time you are 50, but if you take a preventive drug starting when you are 40, the chance will drop to 2 percent.
The Human Genome Project has given us a genetic parts list.
Every cell in our body, whether it's a bacterial cell or a human cell, has a genome. You can extract that genome - it's kind of like a linear tape - and you can read it by a variety of methods. Similarly, like a string of letters that you can read, you can also change it. You can write, you can edit it, and then you can put it back in the cell.
Genome-based treatment, based on wider and cheaper availability of genome data, will provide new ways to customize the therapeutic protocol and enhance our control over diseases and medical treatment.
Eventually we'll be able to sequence the human genome and replicate how nature did intelligence in a carbon-based system.
Evolution is all about passing on the genome to the next generation, adapting and surviving through generation after generation. From an evolutionary point of view, you and I are like the booster rockets designed to send the genetic payload into the next level of orbit and then drop off into the sea.
I thought we'd just sequence the genome once and that would be sufficient for most things in people's lifetimes. Now we're seeing how changeable and adaptable it is, which is why we're surviving and evolving as a species.
It will be the mother of all telescopes, and you can bet it will do for astronomy what genome sequencing is doing for biology. The clumsy, if utilitarian, name of this mirrored monster is Large Synoptic Survey Telescope, or LSST. You can't use it yet, but a peak in the Chilean Andes has been decapitated to provide a level spot for placement.